The role of polymorphic loci of the cytokine gene IL6 (C174G) in inflammatory and ulcerative lesions of the stomach

Purpose of the study. To study distribution and role polymorphic loci cytokine gene IL6 (C174G) in inflammatory ulcerative lesions stomach. Material research methods. In this study, detection was carried out patients with stomach (n=96) healthy individuals (n=88). Results. Analysis features polymorphism among studied groups diseases compared ones, its contribution to pathogenetic mechanisms their formation found, which is confirmed by presence a pronounced tendency increase frequencies major C allele 3.3 times (χ 2 = 3.3; P=0.1) C/C genotype 2.9 =2.9; chronic non-atrophic gastritis (CNG), as well minor G 2.5 =2.5; P=0.2) (GU). addition, genetic marker also 3.1 =1.9; 2.8 =1.4; P=0.3; OR=2.8; 95%CI: 0.52-15.37) CNG those group erosive (CEG), statistically significant these indicators 5.8 =6.6; P=0.025) 6.2 6.3; P=0.025), respectively, comparison GU. No association between likelihood C174G found individuals. However, GU, trend towards CEG 1.9 =2.0; 2.2 =2.1; P=0.2). Conclusions: based on results it can be argued that play Uzbekistan.